Development and Validation of the PICK-UP-STRICS Score to Predict Fibrostenosis in Patients with EoE Prior to Endoscopy.

ABSTRACT:

Background

Predicting fibrostenotic complications prior to endoscopy in eosinophilic esophagitis (EoE) is challenging and esophageal strictures and narrowing are commonly missed on endoscopy.

Aim

To develop and validate a score to predict fibrostenosis in EoE patients prior to endoscopy.

Methods

We leveraged a large database of newly diagnosed EoE patients. Fibrostenosis was defined as esophageal stricture, luminal narrowing, or dilation performed during the diagnostic endoscopy. Patients were randomly divided into a development and validation set. We compared features between patients with and without fibrostenosis to inform the initial model and assess predictive ability, as measured by area under curve (AUC). We tested the model in the independent validation set an

SUBMITTER: Chang JW 

PROVIDER: S-EPMC12269376 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature