Clinical relevance and outcome of routine endomyocardial biopsy to detect rejection after heart transplantation.

ABSTRACT:

Background

Endomyocardial biopsy has been the cornerstone of monitoring rejection after heart transplantation for decades. Although recommendations advise routine biopsies during the first 3-12 months, this timeframe is broad, and intercenter variability persists in its application. Here, we report the yield and complication rate of routine endomyocardial biopsies during the past 36 years of post-transplantation care to monitor acute cellular rejection.

Methods

In this retrospective, single-center study, we collected all routine biopsy data after transplantation between 1986 and 2022. The total number of biopsies, type of rejection, complications, and survival were analyzed in the total population as well as per different endomyocardial biopsy protocol over time period (Peri

SUBMITTER: Kieviet LC 

PROVIDER: S-EPMC12269405 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature