Effects on mortality of extended versus short-term anticoagulation in venous thromboembolism: a systematic review and meta-analysis of randomized trials.

ABSTRACT:

Background

Venous thromboembolism (VTE) is a common disease, particularly in older age. In 30% of cases the VTE is unprovoked, with a risk of recurrence and therefore of mortality that is higher in these patients. The duration of anticoagulation is still a matter of debate: standard or short-term (3-6 months) versus extended (no end date).

Objectives

To analyze the potential benefit of prolonged anticoagulation on overall mortality, according to type and duration of treatments.

Methods

PubMed, EMBASE, and Cochrane were searched to identify randomized controlled trials. They had to be designed to compare 2 anticoagulation strategies in patients with unprovoked VTE: short versus extended. No date restrictions were applied the search was last updated on September 30, 202

SUBMITTER: Lefebvre M 

PROVIDER: S-EPMC12269505 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature