Perturbations in L-serine metabolism regulate protein quality control through the sensor of the retrograde response pathway RTG2 in Saccharomyces cerevisiae.

ABSTRACT: Cellular protein homeostasis relies on a complex network of protein synthesis, folding, sub-cellular localization, and degradation to sustain a functional proteome. Since most of these processes are energy-driven, proteostasis is inescapably afflicted by cellular metabolism. Proteostasis collapse and metabolic imbalance are both linked to aging and age-associated disorders, yet they have traditionally been studied as separate phenomena in the context of aging. In this study, we indicate that reduced proteostasis capacity is a result of a metabolic imbalance associated with age. We observed increased accumulation of L-serine and L-threonine in replicative old cells of Saccharomyces cerevisiae, indicating an imbalance in amino acid metabolism with replicative aging. Replicating this metaboli

SUBMITTER: Saxena K 

PROVIDER: S-EPMC12269516 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature