Trajectory of plasma lipidome associated with the risk of late-onset Alzheimer's disease: a longitudinal cohort study.

ABSTRACT:

Background

Comprehensive lipidomic studies have demonstrated strong cross-sectional associations between the blood lipidome and late-onset Alzheimer's disease (AD) dementia and its risk factors, yet the longitudinal relationship between lipidome changes and AD progression remains unclear.

Methods

We employed longitudinal lipidomic profiling on 4730 plasma samples from 1517 participants of the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort to investigate the temporal evolution of lipidomes among diagnostic groups. At baseline (n = 1393), participants were classified as stable diagnosis status including stable AD (n = 243), stable cognitive normal (CN; n = 337), and stable mild cognitive impairment (MCI; n = 413), or converters (AD converters: n = 329; MCI converter

SUBMITTER: Wang T 

PROVIDER: S-EPMC12269576 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature