A systematic review and meta-analysis of noradrenaline compared to adrenaline in the management of septic shock.

ABSTRACT:

Background

Septic shock is associated with significant mortality. The International Surviving Sepsis Campaign guidelines recommend noradrenaline as first-line vasopressor, whilst South African guidelines recommend adrenaline. Clinical trials show similar efficacy but suggest safety advantages for noradrenaline. We reviewed the evidence comparing noradrenaline and adrenaline in the initial management of adult patients with septic shock.

Methods

We searched PubMed, Epistemonikos, Cochrane Library, and clinical trial registries for clinical practice guidelines, health technology assessments, and systematic reviews of randomised controlled trials (RCTs) through July 2024. We appraised these using AGREE II and AMSTAR 2 tools and assessed eligible RCTs extracted from systematic re

SUBMITTER: Leong TD 

PROVIDER: S-EPMC12269591 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature