Genetic deficiency of EXOSC10 ribonuclease disrupts spermatogenesis and male fertility in mice.

ABSTRACT: Male germ cell meiosis is essential for the generation of haploid spermatozoa in mammals. Oocyte-specific KO of Exosc10 results in female subfertility by impairing germinal vesicle breakdown and disrupting the transcriptome during oocyte maturation. However, the involvement of EXOSC10 in the regulation of male germ cell meiosis remains poorly understood. This study explores the pivotal role of EXOSC10 ribonuclease in male germ cell meiosis in mice. Conditional deletion of Exosc10 in premeiotic germ cells impedes spermatogonial differentiation and obstructs meiotic progression in spermatocytes, characterized by abnormal synapsis and defective meiotic recombination. These disruptions lead to heightened apoptosis, defective meiosis, compromised spermatogenesis, and resultant male sterility. S

SUBMITTER: Yu J 

PROVIDER: S-EPMC12269607 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature