Outbreak and epidemic of Getah virus infection in swine by virulence-enhanced GIII variant in Henan, central China in 2024.

ABSTRACT: The Getah virus (GETV), an emerging mosquito-borne virus, poses a threat to many animal species and probably even humans. Between late July and mid-September, concentrated outbreaks of GETV on pig farms have occurred in multiple regions across Henan, and showed epidemic characteristics. To investigate the genetic characteristics and virulence changes of GETV strains responsible for the GETV epidemic in Henan, a total of 27 GETV strains were isolated from 31 commercial pig farms located in 21 counties. Phylogenetic and sequence alignment analysis results showed that 22 of the isolates formed a distinct cluster within the phylogenetic tree, and the strains in this cluster exhibited 3 amino acid mutations in the non-structural protein nsP3 along with an amino acid mutation in the structural p

SUBMITTER: Sun Y 

PROVIDER: S-EPMC12269664 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature