IscR-tmRNA regulatory axis plays a key role in multiple stress response and pathogenicity in <i>Aeromonas veronii</i>.

ABSTRACT: Bacterial pathogens intricately modulate their response to a variety of stress and the virulence, particularly in light of the dynamic conditions both in natural habitat and within host organisms. Transfer-messenger RNA (tmRNA), which plays an important role in pathogenicity due to its major function in the trans-translation system for ribosome rescue, has been proved as a stress response molecule. Herein, our results indicate that the global regulator IscR acts as a crucial activator responsible for the expression of tmRNA in Aeromonas veronii, a bacterial pathogen posing significant challenges to both aquatic industry and public health. Bacterial one-hybrid and electrophoretic mobility shift assays (EMSA) confirm the direct binding of IscR to the promoter region of the ssrA

SUBMITTER: Ma X 

PROVIDER: S-EPMC12269673 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature