Identification of the important role of CA9 in immune infiltration and prognosis in cervical cancer.

ABSTRACT:

Aim

This study aimed to investigate the association between CA9 expression and the immune infiltration and prognosis of CC.

Materials & methods

The GSE9750 dataset in the GEO database, the UALCAN database, and the cBioPortal of cervical squamous cell carcinoma study were used for bioinformatic analysis, followed by validation via immunohistochemistry in clinical samples.

Results

Compared to normal controls, CC samples showed 1175 significantly downregulated and 698 significantly upregulated genes, respectively. Specifically, CA9 was identified among the up-regulated genes, with verification by analysis of TCGA data. The overexpression of CA9 in CC was further confirmed in clinical samples. The protein-protein interaction network results revealed that CA9 was closely a

SUBMITTER: Zhao Z 

PROVIDER: S-EPMC12269681 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature