GrimAge and GrimAge2 Age Acceleration effectively predict mortality risk: a retrospective cohort study.

ABSTRACT: Epigenetic clocks have been widely applied to assess biological ageing, with Age Acceleration (AA) serving as a key metric linked to adverse health outcomes, including mortality. However, the comparative predictive value of AAs derived from different epigenetic clocks for mortality risk has not been systematically evaluated. In this retrospective cohort study based on 1,942 NHANES participants (median age 65 years; 944 women), we examined the associations between AAs from multiple epigenetic clocks and the risks of all-cause, cancer-specific, and cardiac mortality. Restricted cubic spline models were used to assess the shape of these associations, and Cox proportional hazards regression was employed to quantify risk estimates. Model performance was compared using the Akaike Information Cri

SUBMITTER: Zhu T 

PROVIDER: S-EPMC12269703 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature