Carnosol attenuates Acinetobacter baumannii virulence by interfering with indole-mediated quorum sensing.

ABSTRACT: Many bacterial pathogens utilize quorum sensing (QS) signals to modulate the biological functions in a cell density-dependent manner. Acinetobacter baumannii is a harmful pathogen and a major cause of hospital-acquired infections due to its severe drug-resistance and pathogenic nature. Therefore, the development of innovative antibacterial strategies for A. baumannii infections is important. Earlier studies have proved that A. baumannii utilizes N-acyl-L-homoserine lactones (AHLs) and indole signalling systems to modulate its biological functions and virulence. Here, we report that carnosol, which is isolated from Salvia officinalis L. (S. officinalis), inhibited the pathogenicity of A. baumannii by interfering with indole-mediated quorum sensing.

SUBMITTER: Cui B 

PROVIDER: S-EPMC12269709 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature