Small and Stable Pancreatic Cysts Are Reassuring During Surveillance: Results From the PACYFIC Trial.

ABSTRACT:

Background

Pancreatic cysts are increasingly discovered on imaging studies performed for unrelated conditions. Currently, surveillance of these lesions poses a substantial burden on patients, and health care recourses. We hypothesized that individuals with small and stable cysts have a diminutive risk of progressing to high-grade dysplasia (HGD) or pancreatic cancer (PC) that is similar to that in the general population.

Methods

This nested PACYFIC-study is a collaboration among 44 centers in Europe and Northern-America, and investigates the risk of HGD and PC for different cyst sizes and growth rates in participants without baseline worrisome features (WF) or high-risk stigmata (HRS).

Results

Of the 2369 PACYFIC participants, 975 met the inclusion criteria, with a me

SUBMITTER: Levink IJM 

PROVIDER: S-EPMC12269727 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature