Multiplexed polypeptide-based hybrid bacterial clusters by tailoring the conjugation for synergistic treatment of infected wounds.

ABSTRACT: Drug-resistant bacterial infections and excessive inflammation pose serious challenges to wound healing. Currently, biomaterial-assisted antibacterial therapies demonstrate excellent therapeutic potential by enriching antibacterial agents at the site of infection and combining the advantages of multiple therapeutic agents. Here, inspired by bacterial aggregation behaviors in living organisms that regulate host physiological activities, a biomimetic polypeptide-based hybrid bacterial cluster is reported for treatment of infected wounds (PTS-UGT). Specifically, hybrid bacteria (UGT) were first constructed by a method of stepwise biological self-assembly with Staphylococcus epidermidis (SE) bacterial surface growth of gold and silver particles (UG) and polyphenolization of gold and silver par

SUBMITTER: Xiao J 

PROVIDER: S-EPMC12269884 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature