Comprehensive transcriptomic analysis of hepatocellular Carcinoma: Uncovering shared and unique molecular signatures across diverse etiologies.

ABSTRACT: Hepatocellular carcinoma (HCC) is a leading cause of cancer mortality, often diagnosed at advanced stages where treatment options are limited. This study undertakes a comprehensive meta-analysis of gene expression profiles from 19 independent datasets sourced from the Gene Expression Omnibus (GEO), encompassing a diverse range of HCC etiologies, including HBV and HCV infections, cirrhosis, and normal liver comparisons. Our analysis identified 125 genes consistently altered across all datasets (e.g., CYP2C9, SLC22A1, RDH5) that represent a pan-etiology HCC signature, implicating retinol metabolism and solute transport as key pathways in HCC pathogenesis. Notably, 14 HBV-specific differentially expressed genes (DEGs) (e.g., ABCA8, GADD45B) and 221 HCV-speci

SUBMITTER: Khorsand B 

PROVIDER: S-EPMC12269975 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature