BMSCs-targeting piezoelectric stimulation and immunomodulatory dual-functional hydrogel for promoting diabetic bone regeneration.

ABSTRACT: Bone regeneration in diabetic patients poses a significant clinical challenge due to persistent hyperglycemia and chronic inflammation, which disrupt the crucial interaction between the immune microenvironment and bone marrow-derived mesenchymal stem cells (BMSCs), thereby impairing osteogenesis. To address this limitation, ultrasonic-responsive barium titanate (BTO) nanoparticles were coated with BMSC membranes (B-TNs) and subsequently integrated into a carboxylated modified silk fibroin (CMS) hydrogel. This resulted in a dual-functional B-TNs@CMS composite hydrogel designed to combine targeted BMSC stimulation with immunomodulatory properties. Under diabetic conditions, the composite hydrogel facilitated macrophage polarization from the pro-inflammatory M1 phenotype to the anti-inflammat

SUBMITTER: Dong J 

PROVIDER: S-EPMC12269990 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature