The arrow of time in Parkinson's disease.

ABSTRACT:

Background

Parkinson's disease (PD) is a system-level disorder that implicates brain network dynamics across multiple scales. Detecting the 'arrow of time', or temporal reversibility of the brain's information processing flow enables quantification of equilibrium in the brain and inferences on the hierarchical organization. Therefore we aimed to explore disturbances in resting-state equilibrium levels as well as changes in the hierarchical organization due to PD.

Methods

Structural and functional MRI of 29 PD patients and 19 healthy controls were acquired and analyzed. Empirical non-reversibility was computed as the distance between time-shifted forward- and artificially-reversed time series. Levels of equilibrium were subsequently assessed globally and within two cortico-su

SUBMITTER: Sadeghi F 

PROVIDER: S-EPMC12269992 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature