In vivo cortical microstructure mapping using high-gradient diffusion MRI accounting for intercompartmental water exchange effects.

ABSTRACT: In recent years, mapping tissue microstructure in the cortex using high gradient diffusion MRI has received growing attention. The Soma And Neurite Density Imaging (SANDI) explicitly models the soma compartment in the cortex assuming impermeable membranes. As such, it does not account for diffusion time dependence due to water exchange in the estimated microstructural properties, as neurites in gray matter are much less myelinated than in white matter. In this work, we performed a systematic evaluation of an extended SANDI model for in vivo human cortical microstructural mapping that accounts for water exchange effects between the neurite and extracellular compartments using the anisotropic Kärger model. We refer to this model as in vivo SANDIX, adapting the nomenclature from previous publ

SUBMITTER: Dong T 

PROVIDER: S-EPMC12270005 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature