Sociability genetically separable from social hierarchy in amniotes.

ABSTRACT: Sociability and social hierarchy are two essential features to form a social group. However, it remains unknown whether sociability and social hierarchy are genetically separable. In this study, we examined the social hierarchy, social and social novelty preference of PAS1 knock-out and knock-in mice. PAS1 (placental-accelerated sequence 1) is an enhancer that modulates social hierarchy. We found that PAS1 knock-out mice lack social hierarchy while wallaby/chicken PAS1 knock-in mice establish stable social ranks. Moreover, social and social novelty preference was observed in all PAS1-mutant mice. PAS1 knock-in mice have stronger preference to interact with other mice than wild-type mice (C57BL/6). All PAS1-mutants have neither stress/aggression-like behavior nor olfactory impairment. Overa

SUBMITTER: Lin X 

PROVIDER: S-EPMC12270018 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature