Chromosome 21 variants tied to severe asthma exacerbations: A genome-wide association study in a Brazilian population.

ABSTRACT:

Background

Asthma exacerbations are episodes of symptom worsening requiring increased therapy, which affect patients across all asthma severities. Potential genetic associations with asthma exacerbations in an understudied population were investigated.

Objective

We sought to perform a genome-wide association study on severe asthma exacerbations in an admixed adult population with varying asthma severities and to explore potential epigenetic roles.

Methods

A genome-wide association study was conducted in 727 Brazilian patients (mean age, 43 years; 20% male; and 55% with exacerbations) from the Programa de Controle da Asma na Bahia study, analyzing 12 million variants. Severe exacerbation was defined as systemic corticosteroid use for 3 or more days, emergency room visi

SUBMITTER: de Santana MBR 

PROVIDER: S-EPMC12270054 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature