Tobacco Smoking and Gray Matter Volume in Individuals at Clinical High Risk for Psychosis: A Longitudinal Magnetic Resonance Imaging Study.

ABSTRACT:

Background

Smoking is pervasive in young adults before psychosis onset and has been linked to worse clinical outcomes. Research suggests that smoking may play a role in psychosis pathogenesis, as increased smoking and gray matter reductions are associated with psychosis risk. However, a direct relationship in people at clinical high risk for psychosis (CHR-P) has not been established.

Methods

3T structural magnetic resonance imaging scans from the NAPLS-3 (North American Prodrome Longitudinal Study 3) were used. At baseline, 432 CHR-P nonsmokers and 110 CHR-P smokers were included, totaling 1617 scans across 2-, 4-, 6-, and 8-month follow-ups. Baseline gray matter volume differences between smoking and nonsmoking CHR-P were assessed with voxel-based morphometry. Linear mixed

SUBMITTER: Koster M 

PROVIDER: S-EPMC12270062 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature