Metabolic consequences of altered kidney glucose reabsorption under normoglycemic conditions.

ABSTRACT:

Objective

Kidney glucose reabsorption, primarily mediated by glucose transporter 2 (GLUT2), is essential for systemic glucose homeostasis. While GLUT2's role has been studied in diabetic conditions, its function in kidney proximal tubule cells (KPTCs) under normo-physiological conditions remains unclear. This study aimed to delineate the metabolic consequences of KPTC-specific GLUT2 deletion on renal and whole-body energy homeostasis.

Methods

We utilized a conditional mouse model with KPTC-specific deletion of GLUT2 to assess the impact of impaired renal glucose reabsorption on systemic metabolism. Comprehensive metabolic and behavioral phenotyping, tissue-specific glucose uptake assays, and multi-omics analyses were performed to evaluate changes in energy balance, organ-spe

SUBMITTER: Ahmad M 

PROVIDER: S-EPMC12270078 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature