Ferrocene thiazolidine-2,4-dione derivatives cause DNA damage and interfere with DNA repair in triple-negative breast cancer cells.

ABSTRACT: In this study, ferrocene-containing thiazolidine-2,4-dione derivatives were screened against triple-negative breast cancer (TNBC) cell lines, which represent an aggressive subtype of the disease predominant in women of African descent. The lack of key receptors in TNBC poses a therapeutic challenge as there are limited targeted treatment options available for this subtype. The ferrocene thiazolidine-2,4-dione derivatives displayed toxicity against HCC70 TNBC cells in the low-moderate micromolar range (5-46 μM) and two compounds were selected for further study, with IC50 values of 7.54 ± 1.07 μM (OY25) and 5.59 ± 1.24 μM (OY29). Additionally, compounds OY25 and OY29 were screened against other cancer and non-tumourigenic cell lines and found to be less toxic against non-cancerous breast epi

SUBMITTER: Vukea N 

PROVIDER: S-EPMC12270111 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature