Influence of renal function and daptomycin dose on clinical effectiveness and adverse events in Japanese pediatric patients: A multicenter retrospective observational study.

ABSTRACT:

Background

Data on the clinical effectiveness and adverse events of daptomycin in pediatric patients, considering dosage and renal function, are limited.

Aim

In this study, we aimed to investigate the clinical effectiveness of daptomycin, incidence of related adverse events, and associations between clinical outcomes and risk factors, including dosage and renal function, in pediatric patients.

Methods

Medical records of pediatric patients treated with daptomycin between September 2011 and December 2022, were retrospectively reviewed. Clinical effectiveness was categorized as cure, improvement, failure, or non-evaluable. The clinical success rate was defined as the sum of cured and improved cases. We classified doses based on the approved ranges: underdose (>1 mg/kg le

SUBMITTER: Shiraishi C 

PROVIDER: S-EPMC12270112 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature