Impact of the entorhinal feed-forward connection to the CA3 on hippocampal coding.

ABSTRACT: Each sub-region of the hippocampus plays a critical computational role in the formation of episodic learning and memory, but studies have yet to show and interpret the individual spiking dynamics of each region and how that information is passed between each subregion. This is in part due to the difficulty in accessing individual communicating axons. Here, we created a novel microfluidic device that facilitates network growth of four separated hippocampal subregions over a micro-electrode array. This device enabled monitoring single axons over two electrodes so direction of spike propagation in interregional communication could be ascertained. In this in vitro hippocampal study, we compared spiking dynamics across two novel four-compartment device architectures: one with four sets of axon

SUBMITTER: Lassers SB 

PROVIDER: S-EPMC12270128 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature