Association between estimated glucose disposal rate and major adverse cardiovascular events in patients with type 2 diabetes.

ABSTRACT:

Background

Estimated glucose disposal rate (eGDR) is associated with risk of adverse outcomes in patients with type 2 diabetes. However, whether eGDR affects long-term glycemic management in patients with type 2 diabetes remains unclear. This study aimed to investigate the relationships between eGDR, long-term visit-to-visit HbA1c variability, and adverse outcomes in patients with type 2 diabetes.

Methods

This post-hoc analysis of the Action to Control Cardiovascular Risk in Diabetes study (ACCORD) included 10,129 type 2 diabetes patients with high cardiovascular risk. Participants were divided into tertiles based on eGDR values. HbA1c variability was assessed using the HbA1c Variability Score (HVS). Primary outcome was major adverse cardiovascular events (MACEs), composite

SUBMITTER: Liu M 

PROVIDER: S-EPMC12270132 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature