Sex-dependent effects of a gestational ketogenic diet on offspring birth and lifespan.

ABSTRACT: Low-carbohydrate, high-fat ketogenic diets (KDs) are used for treating drug-resistant epilepsy, and other potential benefits, such as treating neurological disorders, metabolic syndrome, and cancer are being explored. In addition to these and other medical applications, KDs have also become popular for rapid weight-loss and enhancing athletic performance. However, the potential negative effects of exposing developing offspring to KDs during pregnancy (gestational KD) are poorly understood, and especially the long-term health consequences. In this study, we investigated the effects of a partial gestational KD administered during the second half of pregnancy and assessed the consequences on the offspring over their entire lifespan. We found that, compared to controls, a gestational KD signif

SUBMITTER: Zala SM 

PROVIDER: S-EPMC12270155 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature