Intensive luteal phase support in hormone replacement and modified natural cycle frozen embryo transfers in ovulatory patients: A propensity score-matched study.

ABSTRACT:

Background

The optimal endometrial preparation protocol for frozen embryo transfer (FET) remains controversial, with different cycle regimens and luteal phase support strategies across studies yielding conflicting results. This study aimed to compare the pregnancy outcomes of modified natural cycles (mNC) versus hormone replacement therapy (HRT) cycles, both with intensive luteal support using vaginal micronized progesterone and oral dydrogesterone.

Methods

This retrospective cohort study included 2365 FET cycles (1892 HRT and 473 mNC) in ovulatory women. Both groups received vaginal progesterone (800 mg/day) and oral dydrogesterone (30 mg/day) from the day after ovulation trigger or upon progesterone initiation. Propensity score matching was used to balance baseline charact

SUBMITTER: Nguyen HTL 

PROVIDER: S-EPMC12270165 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature