Sexually-dimorphic neurons in the <i>Drosophila</i> whole-brain connectome.

ABSTRACT: Sexual dimorphisms are present across brains. Male and female brains contain sets of cell types with differences in cell number, morphology, or synaptic connectivity between the two sexes. These differences are driven by differentially-expressed transcription factors, which set the stage for disparate sexual and social behaviors observed between males and females, such as courtship, aggression, receptivity, and mating. In the Drosophila brain, sexual dimorphisms result from differential expression of two transcription factors, Fruitless (Fru) and Doublesex (Dsx), and genetic reagents driven by enhancers for Fru and Dsx label sexually-dimorphic neurons in both male and female brains. The recent release of the first whole-brain connectome for Drosophila provides a unique opport

SUBMITTER: Deutsch D 

PROVIDER: S-EPMC12270219 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature