β-caryophyllene regulates H3K36me3 to inhibit spore germination and mycelial growth of Fusarium proliferatum.

ABSTRACT: Background: Panax notoginseng is a valuable traditional Chinese medicine and is highly susceptible to root rot disease, which is primarily caused by the pathogenic fungus Fusarium proliferatum . The antifungal mechanisms underlying the effects of β-caryophyllene (BCP), which is commonly found in Essential oils (EOs), remain unclear. In this study, RNA sequencing (RNA-seq) and chromatin immunoprecipitation sequencing (ChIP-seq), along with in vitro antifungal experiments, were used to investigate the inhibitory effects of BCP on F. proliferatum . Results: BCP not only influenced the mycelial growth of F. proliferatum but also exerted a pronounced inhibitory effect on spore germination. After treatment with 200 mM BCP, the inhibition ra

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC12270221 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature