Coarse-grained model of serial dilution dynamics in synthetic human gut microbiome.

ABSTRACT: Many microbial communities in nature are complex, with hundreds of coexisting strains and the resources they consume. We currently lack the ability to assemble and manipulate such communities in a predictable manner in the lab. Here, we take a first step in this direction by introducing and studying a simplified consumer resource model of such complex communities in serial dilution experiments. The main assumption of our model is that during the growth phase of the cycle, strains share resources and produce metabolic byproducts in proportion to their average abundances and strain-specific consumption/production fluxes. We fit the model to describe serial dilution experiments in hCom2, a defined synthetic human gut microbiome with a steady-state diversity of 63 species growing on a rich med

SUBMITTER: Mahajan T 

PROVIDER: S-EPMC12270328 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature