Evaluation of Polar Substituted Schiff Bases and 1,2,3-Triazole Hybrids as Anticancer Agents.

ABSTRACT: Polar substituted Schiff bases and 1,2,3-triazole hybrids (2-6) were successfully synthesized by Schiff base condensation reaction between the previously synthesized triazole 1 and series of polar substituted amines. The chemical structures of the hybrids were confirmed using spectroscopies (NMR and FTIR), CHN elemental analysis and single-crystal x-ray diffraction analysis. The compounds were evaluated for their antiproliferative activity against two cancer cells, PC3 (prostate) and MCF7 (breast) cell lines, using the alamarBlue assay method, and camptothecin was employed as a standard. All the compounds exhibited good activity for the proliferation of the cancer cell lines compared to the standard, and their activity is concentration-dependent. Compounds 1, 2, 4 and 5 exhibited good casp

SUBMITTER: Belay Y 

PROVIDER: S-EPMC12270367 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature