Antioxidants and Antidiabetic Potential of Polyphenolic Fractions and Crude Extracts of Rhus typhina Fruit, Punica granatum L. Peel, and Terminalia catappa L. Leaves: In Vitro and In Vivo Evaluation.

ABSTRACT: Rhus typhina (sumac) fruit, Punica granatum (pomegranate) peel, and Terminalia catappa (Indian almond) leaves' extracts and their anthocyanin and non-anthocyanin fractions were assessed in vitro for 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging, ferric reducing power (FRAP), human salivary amylase (HAS), and dipeptidyl peptidase IV (DPP-IV) inhibitory potentials, as well as for their in vivo antidiabetic effects on high-sugar high-fat diet (HSHFD) + streptozotocin (STZ) induced diabetic rats (8-weeks study), by assessing fasting blood sugar, 1 h- and 2 h-oral glucose tolerance tests, serum insulin, homeostatic model assessment (HOMA) analyses, serum creatinine, urea, and blood urea nitrogen. Phytochemical analysis revealed that sumac extract had the highest total phenolic content

SUBMITTER: Nazir M 

PROVIDER: S-EPMC12270376 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature