Early-Life Mild Traumatic Brain Injury Alters Neurodevelopment and Behavior in Mice.

ABSTRACT: Approximately 280 children per 100,000 experience closed-head injuries each year, with over 80% being mild in severity. While most children with mild injuries do not require admission to a hospital and recover well over time, some children experience persistent behavioral and cognitive abnormalities that continue into adolescence. Mild traumatic brain injury (mTBI) during early life has potential to disrupt critical developmental processes and lead to long-term consequences; however, the mechanistic underpinnings of mTBI's effects on brain development remain understudied. Here, we investigated the effects of early-life mTBI on developmental outcomes using a mouse model. Injury was induced on post-natal day 7 by a single weight drop of one of three different impact intensities. Injury resul

SUBMITTER: Corrigan RR 

PROVIDER: S-EPMC12270539 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature