The Impact of Obesity on the Association between Parity and Risk of Type 2 Diabetes Mellitus.

ABSTRACT:

Backgruound

Most studies focus solely on the relationship between parity and type 2 diabetes mellitus (T2DM) risk, providing limited insights into other contributing or protective factors. This study aims to explore the complex relationship between parity and T2DM risk, considering additional factors such as obesity, race, and body composition.

Methods

This prospective cohort study used data from 242,159 women aged 40 to 69 from the UK Biobank, none of whom had T2DM at baseline. Multivariable Cox proportional hazard models were applied to assess the association between parity and T2DM. Subgroup analyses were performed based on body mass index (BMI), waist circumference (WC), and race.

Results

The hazard ratio for T2DM per additional child was 1.16 (95% confidence inte

SUBMITTER: Gen Y 

PROVIDER: S-EPMC12270591 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature