Diverse Cre recombinase expression pattern in Albumin-Cre driver rats.

ABSTRACT: Rats (Rattus norvegicus) have been widely utilized as model animals due to their physiological characteristics, making them suitable for surgical and long-term studies. They have played a crucial role in biomedical research, complementing studies conducted in mice. The advent of genome editing technologies has facilitated the generation of genetically modified rat strains, advancing studies in experimental animals. Among these innovations, Cre-driver rat models have emerged as powerful tools for spatiotemporal control of gene expression. However, their development and characterization remain less advanced compared to mouse models. In this study, we developed liver-targeting Cre knock-in rats and reporter knock-in rats to evaluate Cre recombinase expression profiles in different genetic con

SUBMITTER: Ishida S 

PROVIDER: S-EPMC12270594 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature