Platinum plus etoposide with durvalumab for extensive-stage small-cell lung cancer with untreated brain metastases: a multicenter, single-arm phase II trial (LOGiK2001, SPEED).

ABSTRACT:

Background

The efficacy of immunotherapy combined with platinum-based chemotherapy for untreated brain metastases originating from small-cell lung cancer (SCLC) has remained unclear.

Methods

This multicenter, single-arm phase II study enrolled chemotherapy-naive patients with extensive-stage SCLC who had at least one untreated brain metastasis measuring ≥5 mm. Patients received durvalumab (MEDI4736) combined with platinum-etoposide chemotherapy for four cycles, followed by durvalumab maintenance monotherapy. The primary endpoint was the intracranial response rate, assessed using the modified RECIST for brain metastases, with target lesions defined as ≥5 mm.

Results

A total of 42 patients from 23 institutions were enrolled. Their median age was 70.5 years (range 35-83

SUBMITTER: Shiraishi Y 

PROVIDER: S-EPMC12270619 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature