Acetaldehyde exposure alters fibrin polymerization, fibrinolysis, and fibrin network structure <i>in vitro</i>.

ABSTRACT:

Background

Fibrin(ogen), the primary structural component of blood clots, plays a critical role in thrombosis and hemostasis. Posttranslational modifications to fibrinogen that occur upon exposure to reactive endogenous metabolites or xenobiotics during inflammation and disease alter polymer formation, network structure, or susceptibility to lysis. Acetaldehyde is a reactive byproduct of hepatic ethanol metabolism and ubiquitous environmental pollutant that forms stable adducts with macromolecules. Previous studies report that acetaldehyde impairs the function of multiple coagulation factors, including fibrinogen.

Objectives

The study aimed to test the hypothesis that exposure of fibrinogen to acetaldehyde alters fibrin polymerization, clot structure, and fibrinolysis.

Me

SUBMITTER: Rave S 

PROVIDER: S-EPMC12270645 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature