The impact of biological interventions on health-related quality of life in adults with Crohn's disease: a systematic review with meta-analysis.

ABSTRACT:

Background

Health-related quality of life (HRQoL) is one of the main issues in Crohn's disease (CD). We systematically assessed the effects of a biological treatment on HRQoL in adults with CD.

Methods

We searched MEDLINE, EMBASE, and CENTRAL from inception to 26 Jul 2024 for randomised controlled trials (RCTs) investigating the effects of the biological agents approved for CD on HRQoL-related outcomes. Changes in IBDQ (Inflammatory Bowel Disease Questonnaire), SF-36 (The 36-Item Short Form Survey) and EQ-5D scores were evaluated using random-effects meta-analyses to determine if they met a clinically meaningful improvement (CMI). Cochrane's Risk of Bias tool 2 and Grading of Recommendations Assessment, Development, and Evaluation (GRADE) were applied to assess the quality a

SUBMITTER: Benic MS 

PROVIDER: S-EPMC12270664 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature