Multimodal Imaging and Dark-Adapted Chromatic Perimetry in BEST1 Vitelliform Macular Dystrophy: Identification of Outcome Measurements.

ABSTRACT:

Objective

To characterize longitudinal multimodal imaging characteristics of Best vitelliform macular dystrophy (BVMD) and describe novel outcome measurements for future clinical trials.

Design

A single-center retrospective cohort study.

Subjects

A total of 36 eyes of 18 patients with genetically and clinically confirmed diagnoses of BVMD were evaluated.

Methods

Patients underwent complete ophthalmic examination and multimodal imaging including spectral-domain OCT and short-wavelength autofluorescence. Dark-adapted chromatic (DAC) perimetry was obtained in 8 of 18 patients.

Main outcome measures

Longitudinal changes in lesion width, area, and measures of retinal thickness, including outer nuclear layer (ONL) thickness, were evaluated as primary outcome m

SUBMITTER: Lima de Carvalho JR 

PROVIDER: S-EPMC12270738 | biostudies-literature | 2025 Sep-Oct

REPOSITORIES: biostudies-literature