Yield of esophageal biopsy patterns for the diagnosis of eosinophilic esophagitis.

ABSTRACT:

Background and aims

The pattern of inflammation in eosinophilic esophagitis (EoE) is patchy, necessitating multiple biopsies to optimize diagnostic yield. Current consensus-based guidelines recommend 6 total biopsy samples at 2 sites, distal and either middle or proximal esophagus, although this recommendation is based on limited data. We aimed to determine whether this biopsy protocol sufficiently captures EoE diagnoses by evaluating the distribution of eosinophilia in a large EoE cohort.

Methods

This was a retrospective study of consecutive patients newly diagnosed with EoE with ≥2 esophageal segments biopsied. Demographic variables, clinical characteristics/history, endoscopic findings, and histologic results were manually reviewed. Distribution (proximal, middle, and/or

SUBMITTER: Muftah M 

PROVIDER: S-EPMC12270769 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature