The association between temperament and polygenic score for psychopathology from infancy to middle childhood.

ABSTRACT:

Background

Certain temperament characteristics, such as low effortful control and high negative affectivity, are linked to an elevated likelihood for later psychopathology. Although genetic vulnerability has been associated with a number of psychiatric conditions, little work has examined the genetic architecture underlying temperament or the genetic overlap between early temperament profiles and later mental health outcomes. The present study examined associations of polygenic scores for anxiety (PGS-Anxiety) and ADHD (PGS-ADHD) with temperament characteristics in a longitudinal sample of children assessed from infancy through age 7 years.

Methods

Analyses were conducted in a sample of children (European Ancestry n = 476; Full Sample [European and other ancestries] N = 606)

SUBMITTER: Freitag E 

PROVIDER: S-EPMC12270772 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature