PAX1/SOX1 gene methylation as a detection and triage method for triage of high risk HPV-Positive women in cervical cancer screening.

ABSTRACT:

Objective

To evaluate the role of PAX1/SOX1 methylation testing in the triage of HPV-positive patients and compare its performance with traditional screening methods, including HPV genotyping and cytology.

Methods

A study was conducted from February 2024 to October 2024, involving women referred for colposcopy during the "two-cancer screening" in a specific region. Patients were grouped based on histopathological results [normal/cervicitis, cervical intraepithelial neoplasia 1 (CIN1), high-grade squamous intraepithelial lesion (HSIL), cervical cancer] and high-risk human papillomavirus (hrHPV) typing (HPV16/18 positive, other 12 hrHPV positive). Cervical exfoliated cell specimens were collected for PAX1/SOX1 methylation and liquid-based cytology testing. Methylation status w

SUBMITTER: Zhang R 

PROVIDER: S-EPMC12270790 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature