Subcortical shape biomarkers reveal limbic and basal ganglia damage in anti-LGI1 encephalitis.

ABSTRACT:

Introduction

Anti-LGI1 encephalitis is associated with disruptions in large-scale brain network functionality. Although hippocampal atrophy has been structurally characterized, the morphometric patterns of subcortical structures and their surface deformations remain poorly understood. We therefore investigated the shape abnormalities of subcortical structures and their morphological correlations in patients with anti-LGI1 encephalitis.

Methods

This study included 31 patients diagnosed with anti-LGI1 encephalitis and 31 group-matched healthy controls. The mesh-based shape method was performed on the fifteen segmented subcortical structures for vertex-wise analyses. Permutation method based on general linear model was applied for statistical group comparison. Associations with

SUBMITTER: Qiao J 

PROVIDER: S-EPMC12270846 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature