Frailty and risk of gastrointestinal bleeding: a prospective cohort study based on UK biobank.

ABSTRACT:

Introduction

Frailty has been associated with various diseases. However, its impact on gastrointestinal bleeding (GIB) remains largely unexplored. This study investigates the relationship between frailty and the incidence of gastrointestinal bleeding events.

Methods

A total of 352,060 participants from the UK Biobank with no history of gastrointestinal bleeding were included. Baseline frailty status was assessed using the Fried phenotype and categorized as non-frail, pre-frail, or frail. The primary outcome was gastrointestinal bleeding, identified through hospitalization records and death registries. Cox proportional hazard models were used to evaluate the association between frailty and gastrointestinal bleeding incidence.

Results

Among the 352,060 participants (mea

SUBMITTER: Zhang C 

PROVIDER: S-EPMC12270847 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature