The association of essential dietary trace elements and their mixture with cognition: a prospective study.

ABSTRACT:

Background

The association of dietary essential trace elements (ETEs) and their mixture with cognition remains unclear.

Methods

Prospective cohort data on the association between dietary ETEs [e.g., iron (Fe), copper (Cu), zinc (Zn), manganese (Mn), selenium (Se), and iodine (I)] and general cognition were obtained from the UK Biobank (UKB) database. Linear regression and restricted cubic splines (RCS) were used to examine the association between individual dietary ETEs and general cognition, including the identification of the inflection points. The Bayesian kernel machine regression (BKMR) model was applied to analyze the association between a mixture of six ETEs and general cognition, as well as potential interactions among ETEs. Stratified analysis and sensitivity analys

SUBMITTER: Li H 

PROVIDER: S-EPMC12270852 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature