Prospective analysis of metabolic syndrome and inflammation in aortic aneurysm risk: UK Biobank study.

ABSTRACT:

Context/objectives

Metabolic syndrome (MetS) is associated with various diseases, yet its connection with aortic aneurysm (AA) is not well understood. The role of chronic inflammation as a mediator in this relationship also remains unclear. This study explores the combined effects of MetS and inflammation on AA risk.

Methods

Data from 312,505 UK Biobank participants were analyzed to assess the relationship between MetS and AA. Cox proportional hazards regression models evaluated the association, while restricted cubic splines, mediation analyses, interaction assessments, and joint analyses explored the impact of inflammatory indicators, including the low-grade chronic inflammation (INFLA) score.

Results

Over a mean follow-up of 14.6 years, 2,382 participants developed

SUBMITTER: Liu X 

PROVIDER: S-EPMC12270853 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature