Association between genomic features and toxic metal(loid) accumulation in left-sided and right-sided colorectal cancer.

ABSTRACT:

Background

Colorectal cancer (CRC) is a high heterogenous disease of genetic variations, which was influenced by tumor anatomic location and toxic metal(loid) accumulation. Current study aims to investigate genomic heterogeneity of CRC influenced by toxic metal(loid) accumulation based on tumor anatomic location.

Methods

In this study, a total of 94 patients with CRC were recruited including 69 left-sided tumors and 35-right sided tumors. The genomic mutation landscape and microsatellite instability (MSI) of tumors were analyzed. The blood metal(loid) element levels were tested by inductively coupled plasma emission spectrometry (ICP-MS).

Results

A total of 642 somatic variations across 24 genes were identified in 94 CRC patients. The most frequently mutated genes wer

SUBMITTER: Yu S 

PROVIDER: S-EPMC12270859 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature