Assessing thyroid health: phenotypic age compared to chronological age.

ABSTRACT:

Introduction

Aging is associated with thyroid dysfunction, but the role of phenotypic age, a biological aging measure derived from nine clinical biomarkers and chronological age, remains unclear.

Methods

This cross-sectional study included 6,681 adults from the National Health and Nutrition Examination Survey (NHANES, 2007-2012) with complete thyroid function and age data. Participants were grouped into quartiles based on chronological and phenotypic age. Weighted multinomial logistic regression was used to assess the association between aging and thyroid disorders, followed by the use of restricted cubic splines (RCSs) to explore potential nonlinear relationships. Subgroup and sensitivity analyses were conducted to test robustness. Mediation analysis assessed the role of ph

SUBMITTER: Yang D 

PROVIDER: S-EPMC12270862 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature