Role of Estrogen Signaling in Notch Pathway Activation in Sertoli Cells.

ABSTRACT: Sertoli cells constitute a somatic component of seminiferous epithelium in mammalian testis which supports the process of spermatogenesis. These cells are sensitive not only to the male sex hormones androgens, but also to their metabolites, estrogens. In this study, we aimed to explore the action of estrogen signaling in rodent Sertoli cells on the activity of canonical Notch pathway, which provides contact-dependent communication between the cells of seminiferous epithelium. Experiments performed on Sertoli cell line and primary Sertoli cell cultures demonstrated that 17β-estradiol, acting through estrogen receptor 2, enhances Notch1 activation, transcriptional activity of recombination signal binding protein for immunoglobulin kappa J region (RBPJ), interaction of RBPJ with Hes1 promoter

SUBMITTER: Lustofin S 

PROVIDER: S-EPMC12270961 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature